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Image Search Results
Journal: NAR Cancer
Article Title: A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice
doi: 10.1093/narcan/zcac019
Figure Lengend Snippet: Analyses of autoimmune disease-like symptoms in KI mice with or without injection of asunaprevir (ASV) or grazoprevir (GRV). ( A ) Appearance of 12-month-old KI mouse treated with ASV at the age of 4 months. ( B ) Spleen weight of 4–5-month-old male and female WT (light blue, n = 5) and KI (red; males, n = 5; females, n = 6) mice. (C–E) Autoantibody titers in the sera of WT, KI and KI + ASV mice measured using ELISA. Anti-double strand (ds) DNA antibody ( C ), anti-single strand (ss) DNA antibody ( D ) and anti-nucleus antibody (ANA) ( E ) were quantified. Four- to five-month-old mice: WT, n = 8; KI, n = 11. Twelve- to 16-month-old mice: WT, n = 12 (C), n = 10 (D, E); KI, n = 16; KI + ASV, n = 6. ( F , G ) Scores of histological analyses of autoimmune diseases in 4–5-month- and 12–16-month-old WT (blue), KI (grey), or KI + ASV (red) mice. Four- to five-month-old mice: WT, n = 8; KI, n = 11. Twelve- to sixteen-month-old mice: WT, n = 12; KI, n = 16; KI + ASV, n = 6. Data are represented as mean ± SE. ( H , I ) Photomicrographs of histopathological manifestations in 4–5-month-old (H) and 12–16-month-old (i) mice analyzed in (E). Pictures show the most severe parts of each stage. Scale bars: 50 μm for glomerulonephritis, 500 μm for arthritis. P values obtained by unpaired two-tailed t -tests (4–5-month) and Brown-Forsythe Welch ANOVA tests (12–16-month) were shown in the graph. * P < 0.05; *** P < 0.001.
Article Snippet: LEBIS mouse anti-dsDNA ELISA Kit (FUJIFILM Wako Shibayagi, Gunma, Japan), LEBIS mouse anti-ssDNA ELISA Kit (FUJIFILM Wako Shibayagi), and
Techniques: Injection, Enzyme-linked Immunosorbent Assay, Two Tailed Test